Malaria is the most fatal disease; in 2012 it was transmitted to 103 countries, with 3.4 billion people at risk of infection. Plasmodium falciparum is the most common parasite affecting people and lead to the death of million people annually. Quinoline is the common scaffold used for the treatment of malaria. In this study QSAR analysis of various quinoline analogues was performed to know the remarkable impact of different physicochemical properties on bioactivity. The model was generated using buildQSAR and the required equation was also obtained with good correlation coefficient between calculated and observed values of activity.
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